![]() Subjects with previous or current cardiovascular, systemic, metabolic disease, body mass index ≥ 30, visually overt aortic or mitral valve regurgitation in long axis MR images, or treatment with medication (except oral contraceptives, hormone replacement therapy or oral incontinence medication ) were excluded from the study. All subjects had a normal electrocardiogram (ECG) and blood pressure (systolic blood pressure (SBP) ≤ 140 mmHg and diastolic blood pressure (DBP) ≤ 90 mmHg) and had no history of systolic or diastolic hypertension. No subjects were excluded because of poor image quality. The study population consisted of 96 healthy volunteers prospectively recruited by advertisement from the local community (76 adults, age 21–81 and 20 children, age 11–15, all caucasian). We also sought to explore, in a cross sectional study, the normal variation of LV volumes and function in strictly healthy subjects over a wide age range in order to examine the age variation of these parameters. ![]() The aim of the study was, therefore, to suggest clinically usable age and gender specific normal ranges for LV volumes and function using gradient echo CMR at 1.5 T for the second through the eighth decade of life. However, at times, some centers still need to use gradient echo sequences in clinical assessment at 1.5 T. A recent study presented age and gender specific normal ranges for CMR at 1.5 T using a steady state free precession sequence. ![]() Several studies have defined CMR normal ranges of LV volumes and function in limited age ranges, and none of these have examined these parameters over a wide age range in healthy individuals. The need for age and gender specific normal values with CMR is therefore growing. It is of great clinical importance to be able to differentiate between normal and abnormal findings, but this may often prove difficult if adequate normal values are unknown. The clinical use of cardiac magnetic resonance imaging (CMR) has increased lately and a consensus panel report has established clinical indications for cardiovascular magnetic resonance. These findings demonstrate the need for age and gender specific normal ranges for clinical use.įundamental structural and functional properties of the left ventricle including left ventricular mass (LVM), volumes, and function are often assessed in the clinical setting using two dimensional echocardiography. EF showed a rapid decline in adolescence compared to changes throughout adulthood. LV volumes and mass both rise in adolescence and decline with age. LV volumes, mass and function vary over a broad age range in healthy individuals. No gender differences were seen in the youngest, 11–15 year, age range. Compared to adult females, adult males had higher BSA-adjusted values of EDV (p = 0.006) and ESV (p < 0.001), similar SV (p = 0.51) and lower EF (p = 0.014). LVM, ESV and EDV rose during adolescence and declined in adulthood. ResultsĪge and gender specific normal ranges for LV volumes, mass and function are presented from the second through the eighth decade of life. Gender-specific analysis of parameters was undertaken in both absolute values and adjusted for body surface area (BSA). Gradient echo CMR was performed at 1.5 T in 96 healthy volunteers (11–81 years, 50 male). ![]() The aims of the study were to determine age and gender specific normal reference values and to explore the normal physiological variation of these parameters from adolescence to late adulthood, in a cross sectional study. ![]() Knowledge about age-specific normal values for left ventricular mass (LVM), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) by cardiac magnetic resonance imaging (CMR) is of importance to differentiate between health and disease and to assess the severity of disease. ![]()
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